heart failure

How do Physicians Treat Congestive Heart Failure?

Congestive heart failure is precisely what it sounds like; it is a failure of the heart to properly function, and its effects on the body can be devastating. Physicians do their best to treat the symptoms and give the patient the best prognosis possible; however, no true cure for congestive heart failure currently exists.

Heart failure occurs when the heart is unable to properly pump blood throughout the body; as a result, rather than distributing nutrients and oxygen to the tissues and then excreting the excess fluid into the urine the blood pools. This results in either a systemic or localized edema as fluid builds up in the veins and organs, causing swelling of the extremities as well as the organs themselves (this fluid accumulation is responsible for an excessive amount of stress on the heart as fluid accumulates in the pleural cavity as well as the dyspnea, or difficulty breathing, often symptomatic of heart failure). The swelling and lack of oxygen and nutrients will result in permanent damage to the organs if left untreated, providing a very poor prognosis for the patient.

The first stage of treatment generally consists of the administration of extra oxygen to attempt to return the oxygen levels in the tissues to normal. Once oxygen has been administered and a pulse oximeter reveals blood oxygen levels to be acceptable the focus will shift to attempting to treat the fluid build-up in the body. Diuretics will be administered to assist the excess fluid on its path out of the body via the urinary tract, and nitrates are administered to cause the vessels to dilate, allowing blood to flow more freely without the heart having to work quite as hard. Treatment with diuretics is often accompanied by supplemental potassium, as the body will excrete potassium in the urine and long term hypokalemia may result in muscle weakness or paralysis, as well as an increased risk of fatal cardiac arrhythmia.

Patients will often be sent home from the hospital with diuretics, as well as a medication known as an ACE inhibitor (an angiotensin-converting enzyme inhibitor) which prevents the body from creating angiotensin, a substance which raises blood pressure and causes the blood vessels to constrict. An angiotensin II receptor blocker may also be administered if the patient continues to produce angiotensin. Patients may also be treated with vasodilators other than ACE inhibitors, particularly if they have responded poorly to treatments with ACE inhibitors in the past. Nitroglycerin is a common example of this type of medication.

Digitalis, or Digoxin, may be prescribed to strengthen the force of the heart’s contractions, aiding it to push blood throughout the body. Treatment with a beta blocker is also beneficial in cases of heart failure, preventing the heart from beating more rapidly in an attempt to compensate for the poor movement of the blood in the body and placing more stress on the weakened muscle.

Blood thinners are used to prevent the formation of clots in the body that may be caused by the decreased movement of the blood in the vessels. Coumadin and heparin are the most commonly prescribed blood thinners in use today; however, due to an increased risk of bleeding patients taking these medications should undergo coagulation testing regularly.

Lifestyle changes are just as important as medications in the long term treatment of heart failure. Patients should consult with their doctor to establish an appropriate (low sodium) diet and exercise program, and should do at least some moderate exercise daily. Equally important is taking sufficient time to rest every day. The heart pumps more easily when the body is at rest, which is vital to an already overstressed muscle. The nicotine from cigarettes causes an increase in heart rate, blood pressure, and the tendency for clumping in the blood vessels; patients with heart failure should abstain from smoking. Flu or pneumonia can be very difficult for hearts that are failing as they attempt to compensate for the lack of oxygen in the bloodstream being carried to the organs. It is very important that patients receive an annual influenza vaccine, as well as a dose of the pneumococcal vaccine, which will protect them from the pneumococcal bacteria that cause over eighty percent of cases of bacterial pneumonia. Wearing non-constrictive clothing will assist in preventing blood clots and facilitating blood flow to the extremeties, and in cases of extremely warm or extremely cold temperatures it is important that the patient take all precautions necessary to keep the body at an appropriate temperature..

Researchers are still seeking to find a cure for congestive heart failure; however, until that day comes it is extremely important that patients suffering from heart failure follow the treatment plan outlined by their physician. With careful attention to maintaining their condition, the prognosis associated with heart failure increases dramatically.

How Can Stem Cells Be Used to Treat Congestive Heart

How Can Stem Cells Be Used to Treat Congestive Heart Failure?

Heart failure is a devastating blow to the body system, and despite the best efforts of clinicians and researchers often results in permanent organ damage and eventual death. Researchers are fighting to put a stop to the high mortality rate of congestive heart failure, and believe stem cells may be the way to do it.

The possible uses for stem cells have made it a highly published topic in medical journals today. Stem cells are the precursors to every cell in the body, and are primarily produced in the bone marrow in adults. During times of crisis, such as when a patient suffers from leukemia, the spleen and other organs that possessed stem cells during fetal development will take over production. This is the body’s way of maintaining proper cell balances and replenishing itself as old cells die. For example, red blood cells in the circulation only have a lifespan of approximately four months; during that time the hematopoietic stem cells in the bone marrow are continuously producing new rubriblasts, the precursor cells that will over time become mature erythrocytes.

There are several forms of stem cells; for the sake of research scientists are currently focusing on the embryonic and adult varieties. Embryonic stem cells come from a blastocyst, a four to five day old human embryo. During gestation these pluripotent cells will divide and multiply, forming the body and internal organs of the fetus. Embryonic stem cells are highly valued for research for several reasons; they are able to provide large numbers of replenishing cells and have no limitations on what form of cells they can become. The use of embryonic stem cells is highly controversial, however, due to the fact that collection often requires the destruction of the embryo.

There are several methods that have been published in research journals regarding the application of stem cells in the treatment of congestive heart failure. Congestive heart failure results when cells in the heart are dysfunctional or destroyed and the heart is unable to properly pump blood throughout the body. Some patients are able to be treated using mechanical aids or transplant, but this is not always the case. Several years ago a group of patients with no other available options for treatment agreed to be part of a test study regarding stem cells. Autologous stem cells were removed from the marrow and injected into the failing heart tissue through the chest wall. Patients who received this treatment showed marked improvement, presumably as a result of stem cell action. The precise means by which this occurs is still unknown; however, research scientists speculate that the stem cell is either growing new vessels or acting as a beacon to bring other cells in to repair the damaged tissue.

Another possibility regarding stem cells is the growth of tissue for transplant. Hearts available for an organ transplant are not as easily obtained as physicians would desire, and there are often waiting lists years long for every available organ. Stem cells grow readily in a laboratory environment, and if unstimulated to differentiate will reproduce pluripotent daughter cells. This results in a tissue that will essentially adapt to whatever environment it is placed in. Research scientists speculate that with the proper environment essentially grow heart tissue and transplant it to the patient who has suffered heart failure, replacing the dead and damaged tissues with live, vital tissue. This procedure would allow the heart to function more easily and hopefully give the patient a better chance for survival.

With current treatment the prognosis for sufferers of congestive heart failure is grim. At least fifty percent will die within five years of being diagnosed, and those who are not victims of this mortality rate will feel the effects of their heart failure for the rest of their lives. Stem cell research represents a chance for those patients to beat these odds.

How Can Genes Contribute to and Cure Congestive Heart Failure?

It is common knowledge that heart failure follows another severe form of heart damage; however, until now scientists and doctors have had no way to identify those at risk. New research into genes and gene therapy have made them a potential weapon in the fight against heart failure.
Scientists have made several discoveries regarding the role of genes in the detection and treatment of heart failure. Several years ago it was discovered that a small percentage of patients who had suffered heart failure possessed a defect in the gene that allows the body to detect stress signals; in essence, the heart does not know that it is working to hard and is unable to adjust. This percentage may seem insignificant; however, the gene mutation was not present in any of the healthy patients examined. Researchers stress that this is a susceptibility factor, not a cause of congestive heart failure; however, it may be the breaking point when determining if a heart suffering from other disease will fail. Detection of this mutation may allow doctors to identify and treat patients at risk prior to their heart failing rather than after.

This defect is found in the ATP-sensitive potassium channels and is caused by a genetic mutation. The potassium channel regulates potassium and calcium levels in the body. While the heart must have calcium to function, an excess of calcium leads to damage. This is the reason calcium blockers are often given to patients with congestive heart failure. Fortunately, medications to open the potassium channel already exist.

In addition, a defect of the delta-sarcoglycan gene has been seen in hamsters with muscular dystrophy and cardiomyopathy. This gene is the cytoskeleton of muscle fibers, and successful transplant of a normal human delta-sarcoglycan gene has been shown to cause a tremendous improvement in these animals. This is noteworthy because current transplant attempts require open heart surgery. This type of gene transplant is carried on a virus, eliminating the need for surgery.

Scientists had been a bit concerned with using this method of gene therapy due to the need for a systemic effect. There was also some concern that the body’s natural immune system would eliminate the virus of its own accord prior to successful delivery of the gene; however, they believe they have found the best form of virus to successfully slip past the body’s defenses. When transplanting the delta-sarcoglycan gene researchers used a type eight adeno-associated virus, piggybacking the corrective gene onto it as it was inserted into the body. This allowed the gene to be carried to all areas of the body in animals with muscular dystrophy without being destroyed by the body’s own natural immunity.

Gene therapy is still highly experimental, and researchers are unsure yet of the role it will play in the conquest of heart failure; however, this represents a technology that was unavailable thirty years ago. Continuing advancements in technology and medicine’s knowledge of the body’s building blocks may one day unlock the mysteries to the cure of this deadly disease.

Whenever cardiac conditions develop these conditions, weaken or damage your heart, which leads to heart failure. In a weakened condition, the heart over time can no longer keep up with even the normal demands placed on it. The ventricles may become stiff and not fill properly between beats. The heart ventricles stretch (dilate) to the point that the heart cannot pump blood efficiently throughout your body. The failing pump causes blood and fluid to back up throughout your circulatory system. The circulatory system consists of your lungs, legs, feet and ankles. The kidneys retain excess water and sodium. All this builds up is the congestive part of your heart failure. The lung congestion occurs only with left-sided heart failure with fluid backing up into the lungs. The most common cause of right sided heart failure is left sided heart failure.

When the fluid fills up the left side of the heart the pressure in the lungs passes to the right side of the heart, which then fails. The fluid then collects in the abdomen and lower extremities which all leads up to heart failure. Heart Failure develops quickly after a heart attack. The heart failure can also develop after years of high blood pressure or coronary artery disease. A defective valve may cause heart failure. A heart valve replacement in this case will prevent heart failure. A specialist normally does the surgical part, which is a cardiologist.

Many times people think that such things cause heart failure as smoking, being overweight or eating foods high in cholesterol and fat but there is a condition known as idiopathic dilated cardiomyopathy were the heart weakens without explanation. This condition will also cause you congestive heart failure if not properly taken seriously.

You might be suffering from if you have heart failure several conditions. These conditions can weaken your heart over time and be present without you being aware that you have the problem. The follow is a brief description of some conditions that affect the heart:

– The most common cause of heart failure is Coronary artery disease. A process called atherosclerosis, which is a build up of fatty deposits in the arteries. This fatty build up causes the blood to narrow a process called plaque, which leaves chronically deprived of oxygen-rich blood pump less vigorously. A heart attack occurs if an unstable plaque not function well it will cause a blood clot in turn completely blocks the blood flow to an area of the heart muscle. This is one of the most common causes of heart failure.

– There are several other reasons that might cause heart failure but we shall discuss the next highest reason for now. High Blood Pressure (hypertension) is the force of blood pumped by your heart through your arteries. When your blood pressure is high then your heart has to work harder causing failure.

Take your cardiologists advice watch your weight and exercise your on the way to a heart healthy way of life.