Tag: heart attack

Aleve, Vioxx, Celebrex, and Bextra: What You Need to Know

Aleve, Vioxx, Celebrex, and Bextra: What You Need to Know About Arthritis Pain Medications
R.L. Fielding

Aleve, Vioxx, Celebrex and Bextra:What You Need To Know About Arthritis Pain MedicationsRecent controversy about the safety of pain medications for arthritis has left patients and health care professionals alike confused about which medications are safe to use. In fact, a recent survey by the Boston-based Rippe Lifestyle Institute indicated that many people with arthritis are suffering unnecessarily because they have stopped or reduced their use of pain relievers due to confusion about which drugs are considered safe.The survey also showed that now, more than ever, those with arthritis need to understand the benefits and possible side effects associated with all arthritis pain medications. In order to do so, people with arthritis, their caregivers and families must be familiar with recent news about the two types of drugs most commonly used to treat arthritis pain non-selective, non-steroidal anti-inflammatory drugs (NSAIDs), and another group of NSAIDs known as cyclooxygenase-2 (COX-2) specific inhibitors. COX-2 specific inhibitors vs. Other NSAIDsCOX-2 specific inhibitors are the newest members of the NSAID class of medications. Available by prescription only, they became widely used in recent years to reduce joint pain and swelling. COX-2 specific inhibitors work by selectively blocking, or inhibiting, one of the two enzymes associated with inflammation. Some experts think that this selective inhibition may be one reason for some of the negative side effects currently associated with COX-2 specific inhibitors.Non-selective NSAIDs were developed earlier than COX-2 specific inhibitors and have been widely used to relieve arthritis pain and inflammation for many years. Unlike COX-2 specific inhibitors, non-selective NSAIDs inhibit both major enzymes involved in the inflammatory process, COX-1 and COX-2. The non-selective NSAID category includes a number of different medications that are available in both prescription and over-the-counter (OTC) products.Timeline of EventsTo understand the current state of affairs, it is important to understand the sequence of events. The controversy started when a study published in the October 21, 2004, issue of the New England Journal of Medicine cited the COX-2 specific inhibitor, Vioxx as potentially causing major adverse events, including heart attack and stroke, among patients taking the drug. As a result, Merck (the drugs manufacturer) voluntarily withdrew Vioxx from the market. However, in the months following, the safety of the other available COX-2 specific inhibitors such as Celebrex and Bextra, as well as other arthritis pain medications in the non-steroidal anti-inflammatory (NSAID) class, were also called into question.Consequently, in February 2005, the US Food and Drug Administration (FDA) convened a special Advisory Committee, made up of members of the Arthritis and Drug Safety Advisory Committees, to review the cardiovascular safety of these arthritis pain medications.FDA Directive: Stronger Warning Labels for Some Pain MedicationsOn April 7, 2005, taking into account the recommendations of the Advisory Committee, the FDA issued the following directives: Bextra, a COX-2 specific inhibitor manufactured by Pfizer, was withdrawn from the market.All prescription NSAIDs must revise their labeling to include a black box warning that highlights the potential increased risk for cardiovascular (CV) events as well as the potentially life threatening gastrointestinal (GI) bleeding associated with these drugs. Celebrex, the only COX-2 specific inhibitor remaining on the US market, was included in this directive.All OTC NSAIDs (except aspirin) will be required to revise their labeling to include more specific information about the potential for GI and CV side effects, a stronger reminder to follow label instructions, as well as a warning about potential skin reactions.To further evaluate the potential for increased CV risk, the FDA also announced that all NSAIDs must conduct and submit to the FDA a comprehensive review and analysis of pertinent safety data from clinical trials. Aleve (naproxen sodium) is supported by clinical studies conducted to gain approval of naproxen as a prescription product and as OTC that do not provide any evidence of increased risk of cardiovascular events. Treatment Options: What Should Arthritis Patients Know?For some people who suffer from pain associated with arthritis, their symptoms can be managed with exercise, heat/cold therapy, joint protection, assistive devices, weight control, or in some severe cases, surgery. For others, medications are needed to help manage the symptoms associated with arthritis. When taken as directed OTC medications such as Aleve provide a safe and effective way to treat mild to moderate pain of minor arthritis. If patients have questions, they should consult their health care professional about which treatment option is most appropriate.Why Its Important to Treat ArthritisArthritis affects approximately 66 million Americans and is the nations leading cause of disability. There are over 100 different types of arthritis, and they all have different symptoms that vary in severity from person to person. The most common form of arthritis, osteoarthritis, is characterized by the breakdown of cartilage that causes the bones to rub together, resulting in pain, loss of movements and stiffness . Arthritis is usually a chronic condition. For more information on Aleve and naproxen, visit the Aleve website at www.aleve.com. For more information on arthritis pain relief, visit www.arthritis.org. About the Author
R.L. Fielding writes on a number of subjects.

Anxiety -Dont Feel Alone Everyone Experience It

We all experience some level of anxiety every now and then. A few of the more common examples include being put in harm’s way, giving a speech to a roomful of your peers, and getting through an interview for an important job. It’s normal to experience anxiety in such situations. Then there are people who experience anxiety on a frequent basis, and feel anxious when there are no immediate threats present. This type of anxiety requires treatment.

Before we get into some of the treatment options, it’s important to understand what anxiety is, and how it happens.

Anxiety happens when our body reacts to an imagined threat as if it were real. Our breathing and heart rate changes, adrenaline starts flowing, and we sweat as we go into the fight or flight response. There are times when this comes in handy, but the person with an anxiety disorder goes well beyond that point.

While you may be able to live with the occasional bout of anxiety, you should seek treatment if it is causing a negative impact on your life. A negative impact is anything that takes away from your quality of life, and your enjoyment of it. Not going to social events, staying inside due to a fear of the outside world, never stepping out of your “safe zone” because you’re afraid you won’t be able to cope are some common examples.

One of the difficulties of diagnosing anxiety is that many of the symptoms can be related to other conditions. Therefore, the sufferer may assume that they have another medical problem, when in reality they actually have an anxiety disorder. Symptoms can include, but are not limited to: shortness of breath, strong heartbeat, nausea, chest pain, fatigue, headaches, stomach pains, and insomnia. That’s quite a list, isn’t it? Someone with a strong heartbeat and pain in their chest would be fully justified in thinking they were having a heart attack, but it could just be a panic attack.

NOTE: Never assume chest pains are okay unless under the direct guidance of a doctor. Even if you have anxiety, the symptoms of a heart attack should never be ignored.

A person with an anxiety disorder thinks differently. For the sake of example, let’s say snakes make them anxious. Our sufferer sees a picture of a snake, and then his mind and body go into a different state. He sees the picture and thinks about how some snakes are poisonous, and they can bite. “What if,” he thinks to himself, “a snake bites me?” He continues by imagining being bitten, injected with venom, dying, and leaving his family destitute due to his being dead. All of this from seeing a picture!

However, his difficulty is how to stop the snowballing effect of these thoughts when they happen. Many of the treatments for anxiety are intended to stop the thought process, and a sense of calm replaces the sense of anxiety.

Understanding Bad Cholesterol

Cholesterol is a very familiar medical term almost to anyone, particularly the middle age group. It is a common thing the word will never be a part of teen-age lingo. The main reason is, most of the dreaded ailments accompanying “high cholesterol” levels are associated with hypertension, heart failure, diabetes and other long term and acquired conditions, which does not could also happen to younger generation as juvenile complications. To make it clear, when the majority is talking about lowering cholesterol, it is all about alleviating the further progress of bad cholesterol.

There are two kinds of cholesterol accumulating or present in the human body. Bad cholesterol or low-density lipoprotein is harmful because it can cause atheroma. Atheroma is considered to be the plaque of the arteries, commonly referred to as fat streaks. If not watched carefully, accumulation of ‘macrophage white blood cells’ can happen to a child even before the age of 10.

The early symptoms may start as early as 5 years old, while the child grows up and the condition is accumulating quietly in the veins. Most of the time, the exact symptoms are only given prognosis after the onset of heart attack or stroke, which is already too late for the patient. The attack of silent killers may not cause death but chances are it can lead to lifetime disability.

It is debilitating to imagine how high levels of bad cholesterol can cause serious consequences to the body. When most people may appear healthy all the time, cholesterols can only be checked through lab tests. Sometimes it surprises people to find out how high their cholesterol build-up has soared for the past years.

There is no mystery behind the strengthening of bad cholesterol other than high consumption of saturated fats in the diet. In the advent of labels or guides in processed foods like canned goods and other packed products in the groceries, it is easy to see the amount of cholesterol a food has. This is just a small matter on how to grasp the essence of being cholesterol conscious.

The major way to lower down cholesterol levels in the body is to understand how it metabolizes in the body. Cholesterol doe not actually come from diet alone. It is a whole process within where diet is just one of the contributing factor. Good cholesterol aids in the body’s biochemical functioning like producing bile, regulating of vitamins that are fat soluble such as A, K, D, and E.

It also has impact on the synthesis of the body hormone. After cholesterol has been utilized in the body, it excretes as excess lipids in the liver and gall bladder as crystal particles. Because cholesterol is not water soluble, it circulates over and over and gets converted to bad cholesterol (low density lipoproteins). For normal individuals with healthy metabolism, bad cholesterol is minimal and comes in as large quantities. The harmful ones are those that come in many number of small sizes trapped in the veins as accumulated clogs.

When it comes to lowering high cholesterol, basically there is nothing to ponder about genetic weaknesses, the key is watching over food intake. Cholesterol is highly present in animal meats and fats, especially pork and beef. It is easy to watch fatty foods with all the precautions available today. But it takes discipline to live a life with less cholesterol consumption.

Lowering Cholesterol

The human body produces oils and other substances that circulate in the bloodstream. An example is insulin, which is secreted from the pancreas in response to the increase in the amount of sugar coming from the food that the person eats. The cells then absorb this, which gives the individual calories that are used as energy.

Another substance that the body produces naturally is cholesterol. This is also ingested in the food people eat. There are two types of cholesterol namely LDL and HDL.

LDL is better known as bad cholesterol. The reason why it is bad is because too much of this in the system may put the person at risk of suffering from either a heart attack or a stroke.

HDL in simple terms is good cholesterol because its job is to regulate the flow the bad one so this can be filtered out of the persons system. There must be a balanced between the two so the individual is healthy.

Whenever people get a blood test, the patient will see a breakdown of the LDL and HDL in the system. Though not that significant as the first two, doctors pay attention to two other figures namely the total cholesterol and the triglyceride level.

In order to be given a clean bill of health, the patient must stay within a certain range. Those who have less than 200mg/dl in total cholesterol are safe. The same goes for someone who has less than 150mg/dl in the triglycerides.

So what happens if the person goes beyond the limit? In simple terms, the individual is at risk of developing high blood pressure or a heart disease. The good news is that the person can still prevent such a thing from happening.

There are four simple ways to do it and this must be done gradually before something bad really happens to the individual.

The first is to change the diet. This means eating less of those that are high in saturated fats such as red meat and dairy products. This should be changed for fish, fruits, nuts, oatmeal and vegetables.

Studies have shown that those who eat oatmeal regularly are able to reduce the LDL and trigylecerides level in just 2 weeks. Imagine what could happen if this is done even after just a month?

The second is exercise. The body has stored fat after how many years of not engaging in any physical activity. Changing the eating habits can only go so far and sweating it out will increase the metabolic rate thus helping reduce the patients cholesterol levels.

The third, which doesnt happen often, is for the individual to take supplements to aid in the reduction of cholesterol. Examples of these are bible acid resins, ezetimibe, fibric acid, niacin and statins.

These are available in different brands and studies have proven this can lower the cholesterol from 15% to 30% when this is taken in regularly.

Should exercise and dieting not work, the patient must remember that the intake of these drugs has certain side effects. The doctor should explain this before even prescribing this so the individual can choose from the wide range of drugs that can be used to lower ones cholesterol.

Prevention is the best way to combat any disease. A regular checkup at the doctors office will surely save money instead of being confined in the hospital.