How Can Genes Contribute to and Cure Congestive Heart Failure?

How Can Genes Contribute to and Cure Congestive Heart Failure?

It is common knowledge that heart failure follows another severe form of heart damage; however, until now scientists and doctors have had no way to identify those at risk. New research into genes and gene therapy have made them a potential weapon in the fight against heart failure.
Scientists have made several discoveries regarding the role of genes in the detection and treatment of heart failure. Several years ago it was discovered that a small percentage of patients who had suffered heart failure possessed a defect in the gene that allows the body to detect stress signals; in essence, the heart does not know that it is working to hard and is unable to adjust. This percentage may seem insignificant; however, the gene mutation was not present in any of the healthy patients examined. Researchers stress that this is a susceptibility factor, not a cause of congestive heart failure; however, it may be the breaking point when determining if a heart suffering from other disease will fail. Detection of this mutation may allow doctors to identify and treat patients at risk prior to their heart failing rather than after.

This defect is found in the ATP-sensitive potassium channels and is caused by a genetic mutation. The potassium channel regulates potassium and calcium levels in the body. While the heart must have calcium to function, an excess of calcium leads to damage. This is the reason calcium blockers are often given to patients with congestive heart failure. Fortunately, medications to open the potassium channel already exist.

In addition, a defect of the delta-sarcoglycan gene has been seen in hamsters with muscular dystrophy and cardiomyopathy. This gene is the cytoskeleton of muscle fibers, and successful transplant of a normal human delta-sarcoglycan gene has been shown to cause a tremendous improvement in these animals. This is noteworthy because current transplant attempts require open heart surgery. This type of gene transplant is carried on a virus, eliminating the need for surgery.

Scientists had been a bit concerned with using this method of gene therapy due to the need for a systemic effect. There was also some concern that the body’s natural immune system would eliminate the virus of its own accord prior to successful delivery of the gene; however, they believe they have found the best form of virus to successfully slip past the body’s defenses. When transplanting the delta-sarcoglycan gene researchers used a type eight adeno-associated virus, piggybacking the corrective gene onto it as it was inserted into the body. This allowed the gene to be carried to all areas of the body in animals with muscular dystrophy without being destroyed by the body’s own natural immunity.

Gene therapy is still highly experimental, and researchers are unsure yet of the role it will play in the conquest of heart failure; however, this represents a technology that was unavailable thirty years ago. Continuing advancements in technology and medicine’s knowledge of the body’s building blocks may one day unlock the mysteries to the cure of this deadly disease.

Manifestations of Arthritis

Manifestations of Arthritis
Amanda Baker

One of the most common conditions in the United States today is
a debilitating inflammatory disease that affects our joints. It
is estimated that there are over 100 different forms of this
disease and over 40 million people suffer from one form or
another.

Though typically thought to be an affliction of the aging,
arthritis can affect anyone at any time, and with all of the
different forms, each with their own symptoms, it could be hard
to determine just what type of arthritis an individual is
suffering from.

The signs and symptoms of arthritis are varied, though some of
the first symptoms are familiar and easy to recognize. Symptoms
such as general pain or swelling around the joints, an increased
stiffness in the joints in the morning, a cracking sound in the
knees when standing, and joints with a red appearance that feel
warm to the touch are all signs of arthritis.

However, before you rush to purchase an over-the-counter
arthritis treatment, you should talk to your doctor. Your doctor
is the only one who will be able to tell you what form of
arthritis you may have and how to treat it.

Rheumatoid arthritis is one of the most common forms of
arthritis that plagues sufferers. It affects the joints and is a
systemic disease that can affect other organs. Rheumatoid
arthritis symptoms tend to disappear after sometime, but the
problem is still there. The true cause of rheumatoid arthritis
is presently unknown, though many suggest that things such as
infections, fungi, or bacteria are the culprits. However, there
are also those that believe that rheumatoid arthritis is
hereditary. Painful and swollen joints are a common warning sign
of rheumatoid arthritis, followed by muscle pain, extreme
fatigue, redness and warmth at the joints, even a low grade
fever and appetite loss.

Next to rheumatoid arthritis, osteoarthritis is a common
affliction, caused by breaking down of joint cartilage.
Osteoarthritis commonly begins in one joint and typically only
affects the one joint. It does not move to internal organs.
Osteoarthritis commonly affects the knees, hips, hands, and
spine. By the time the pain starts setting in for an
osteoarthritis sufferer, the damage to the affected joint
cartilage could be considerable.

Relieving pain from a form of arthritis can be as simple as
over-the-counter or prescription medication. However, in the
most severe cases, surgery may be necessary. Being overweight
can also play a role in arthritis. Some physicians believe that
a change in diet can ease the pain of arthritis, though there is
a lot of debate on the topic. Regardless, you should speak to
your doctor who can tell you just what form of arthritis you may
have, and what treatment options may work best for you.

About the author:
Amanda Baker writes for http://tobeinformed.com – a website for
health, fitness and wellness information.

How Many Acupuncture Treatments Will it Take?

Acupuncture is a well-established and increasingly accepted treatment procedure for pain, for emotional troubles, and for an ever increasing number of physical ailments. More and more traditional physicians are referring patients to acupuncture clinics for a certain set of problems that may be treated more effectively, and without the side effects of medication. Also, individuals may decide to use an acupuncture clinic as the first choice to heal a disease.

The length of a treatment varies widely from person to person, depending on the particular symptoms, the age of the patient, how long the condition has existed, and the environment of the patient. There also seem to be patients that are naturally responsive to acupuncture, when all the other factors are similar. A patient that is responsive to acupuncture may only require one or two visits, as is the case with a number of children. Adult patients that are responsive generally require one to six visits for a particular symptom or set of symptoms. In other cases, up to twenty visits may be required, depending on the severity and length of time the symptoms have persisted. But even some remarkable cases such as recovery from paralysis may come about after a very long series of treatments.

For some conditions, such as for chronic pain, daily treatments are recommended until the pain subsides. The same is true for clients using acupuncture as a means to help stop drug addiction, which require daily treatments in order to keep the cravings at a minimal level. In a few patients, the initial treatment may aggravate the symptoms. A similar possibility is that there is a marked improvement after the first treatment, which may be followed by an aggravation of symptoms at the next few treatments. These should be reported in detail to the acupuncture practitioner, who may revise the locations of needles for the treatment, depending on the particular patient.

It is always a good idea to consider an acupuncture practitioner for whatever health problem you might have. Some problems respond exceptionally well with acupuncture. Acupuncture has a very good success rate for such symptoms as headaches, head congestion, cramps (menstrual, muscular, or intestinal), pain, depression, fatigue, hemorrhoids, and children’s nervous disorders. Acupuncture treatments have frequent success in the following areas, though not quite the same success rate as in the areas above. These include diarrhea, painful menstruation, eczema, gastric problems, kidney and gall bladder malfunction, nervous disorders, palpitations, rheumatism, shingles, autonomic nervous problems, especially following surgery.

There are a number of other conditions that acupuncture can be effective for, and for these a practitioner should be consulted, as new results are coming out frequently. Currently, it is thought that acupuncture is more helpful for symptoms rather than curing such diseases as tuberculosis, infantile paralysis, and Parkinson’s disease. Acupuncture treatments are sometimes surprisingly effective after traditional medicine has been tried without success. Lets look at two simple cases. In the first, a lady suffered with pain in her ankle for three years, and no standard medical treatment helped. Careful observation of her symptoms by an experienced acupuncture practitioner cured her in three treatments. The second case was of a farmer who had a low grade fever (about 100 degrees) nearly every night for a number of months. Regular physicians could not determine a cause, nor a solution. Regular acupuncture treatment was not effective. The acupuncture practitioner then applied the treatments at the optimal time (very early AM, not during the normal clinic hours), and the fever disappeared permanently. I hope this introduction to some uses of acupuncture may help you or someone you know to better health.

Manage the Pain of Osteoarthritis

Manage the Pain of Osteoarthritis
Kamau Austin

Manage the Pain of Osteoarthritis

The Mayo Clinic refers to osteoarthritis as a “wear and tear”
condition that effects people as they age. It is a degenerative
disease and is the most common form of arthritis. It is one of
the most common causes of disability among adults. More than 20
million people in the United States have the disease.
Researchers project that in the next 25 years over 20% of
Americans-beyond the age of 65 will be at risk for
osteoarthritis.

Today, more than half of the population age 65 or older would
show x-ray evidence of osteoarthritis in at least one joint.
Both men and women have the disease with more men getting the
disease before age 45, and more women getting the disease after
that point.

Osteoarthritis may affect any joint in the body and it is
characterized by a breakdown in the cartilage between the
joints. The most common joints affected are the hips, knees,
lower back, fingers and feet.

Osteoarthritis often develops slowly and quite often there are
no symptoms. A person affected with the disease may not know
that they have it until it is revealed during a routine x-ray.

People with osteoarthritis may have one or more of the following
symptoms.

– Pain in a joint during or after use; or after a period of
inactivity, such as after a night’s sleep. – Pain in a joint
during a change in weather. – Swelling or pain in a joint, after
use. – Bony lumps on the end or middle joints of the hands –
Loss of flexibility

Interestingly, the first year of onset of the disease may bring
acute pain, that then fades within a year or so of its
appearance. This is especially true of osteoarthritis of the
fingers.

The exact cause of osteoarthritis is not known but some
researchers believe that we are more susceptible to
osteoarthritis as we age. It may be caused by a combination of
factors, including being overweight,aging, a previous joint
injury, heredity and muscle weakness.

The pain of osteoarthritis can range from that of a minor
inconvenience for some sufferers, to chronic and debilitating
for others. In cases where pain is severe, joint replacement
surgery may be considered.

There is no cure for osteoarthritis, and treatment is geared
towards reducing pain and increasing joint. Treatment may
include medication, physical therapy, occupational therapy and
self-care.

Pharmaceutical medication is used to treat the pain and may
include, over the counter topical pain relievers that are rubbed
into the skin at the effective joint, NSAIDs and acetaminophen
taken internally to help with pain.

Prescription medications may include COX-2 inhibitors such as
Celebrex may be considered for relieving pain, But both Celebrex
and the recently removed from the market durg, Vioxx, are now
linked with some rather serious side effects including, high
blood pressure, and an increased risk of stroke and heart attack.

For some people, a side effect of living with chronic pain is
depression. Since disturbances in sleep may accompany
osteoarthritis, anti depressants may be prescribed because they
can reduce chronic pain a well as help to alleviate sleep
disturbances.

From time to time a doctor may suggest that an osteoarthritis
patient receive injections of corticosteroid, which when
injected into the joint space can offer some relief from pain
and inflammation.

Surgical procedures can provide pain relief and relieve
disability that may result from the deterioration of the joints.
These procedures may include joint replacement; repositioning
bones and fusing bones.

The surgical procedures and prescription medications may be
overkill in the case where the osteoarthritis sufferer has only
mild pain and inflammation. There is much that the mild or
occasional sufferer can do to alleviate their pain ontheir own.

Life-style changes can help the condition so dramatically that
it is sometimes the only treatment the occasional suffered will
need.

Some things that you can do to help with the pain and stiffness
are: – Exercise regularly – Control your weight – Eat a healthy
diet – Apply heat to alleviate pain – Choose appropriate
footwear to help support your back and hip joints. – Apply cold
for occasional flare-ups – Practice relaxation techniques

In all cases osteoarthritis sufferers can benefit from making
some changes in how they approach everyday activities. – Arm
yourself with information and a “can do” attitude: Work with
your health care professional to take control of your treatment
and actively manage your arthritis. – Make use of a brace or
cane if needed. A brace can greatly help to support a painful
knee. And walking with a cane can help support an ailing hip.

– Keep activity within your limits. Osteoarthritis can make you
prone to fatigue and muscle weakness. Take a short nap or rest
when you fell tired. – Avoid straining your finger joints. Use a
kitchen tool or hot water to help with opening jars and bottles.
Kitchen centers and hardware stores are beginning to carry a
supply of kitchen aids to help with simple tasks that may be
difficult for osteoarthritis sufferers.

– Take breaks. Periodically relax and stretch. – Maintain good
posture. Good posture more evenly distributes your body weight
making it easier to support.

Regardless of the approaches that people take to dealing with
their osteoarthritis almost everyone can benefit from the use of
natural supplements. Glucosamine. is a naturally occurring
substance that has been shown to be extremely effective in
treating osteoarthritis.

Phosoplex is a natural supplement takes glucosamine one step
better by combining it with Bio Cell Collagen II, a
concentration of many elements including glucosamine.

The makers of Phosoplex have a valid point when they tell us
“…If we consume only single elements involved in the complex
process of keeping our joints and other connective tissue
healthy we could only expect partial effectiveness.” Phosoplex
with its full spectrum of essential elements provides broader
nutritional support aiding the overall health of individuals
joints.

More information about Phosoplex can be found at
http://www.bodestore.com/phosoplex.html

About the author:
Kamau Austin is a health and fitness enthusiast and advocate. He
is also the publisher of …
www.healthandfitnessvitality.com .
He writes on a regular basis on timeless health and fitness tips
at the Fit After Forty Blog. See more useful health and fitness
news and tips at…
http://www.healthandfitnessvitality.com/blogs/fitnessblog.htm