Aleve, Vioxx, Celebrex, and Bextra: What You Need to Know

Aleve, Vioxx, Celebrex, and Bextra: What You Need to Know About Arthritis Pain Medications
R.L. Fielding

Aleve, Vioxx, Celebrex and Bextra:What You Need To Know About Arthritis Pain MedicationsRecent controversy about the safety of pain medications for arthritis has left patients and health care professionals alike confused about which medications are safe to use. In fact, a recent survey by the Boston-based Rippe Lifestyle Institute indicated that many people with arthritis are suffering unnecessarily because they have stopped or reduced their use of pain relievers due to confusion about which drugs are considered safe.The survey also showed that now, more than ever, those with arthritis need to understand the benefits and possible side effects associated with all arthritis pain medications. In order to do so, people with arthritis, their caregivers and families must be familiar with recent news about the two types of drugs most commonly used to treat arthritis pain non-selective, non-steroidal anti-inflammatory drugs (NSAIDs), and another group of NSAIDs known as cyclooxygenase-2 (COX-2) specific inhibitors. COX-2 specific inhibitors vs. Other NSAIDsCOX-2 specific inhibitors are the newest members of the NSAID class of medications. Available by prescription only, they became widely used in recent years to reduce joint pain and swelling. COX-2 specific inhibitors work by selectively blocking, or inhibiting, one of the two enzymes associated with inflammation. Some experts think that this selective inhibition may be one reason for some of the negative side effects currently associated with COX-2 specific inhibitors.Non-selective NSAIDs were developed earlier than COX-2 specific inhibitors and have been widely used to relieve arthritis pain and inflammation for many years. Unlike COX-2 specific inhibitors, non-selective NSAIDs inhibit both major enzymes involved in the inflammatory process, COX-1 and COX-2. The non-selective NSAID category includes a number of different medications that are available in both prescription and over-the-counter (OTC) products.Timeline of EventsTo understand the current state of affairs, it is important to understand the sequence of events. The controversy started when a study published in the October 21, 2004, issue of the New England Journal of Medicine cited the COX-2 specific inhibitor, Vioxx as potentially causing major adverse events, including heart attack and stroke, among patients taking the drug. As a result, Merck (the drugs manufacturer) voluntarily withdrew Vioxx from the market. However, in the months following, the safety of the other available COX-2 specific inhibitors such as Celebrex and Bextra, as well as other arthritis pain medications in the non-steroidal anti-inflammatory (NSAID) class, were also called into question.Consequently, in February 2005, the US Food and Drug Administration (FDA) convened a special Advisory Committee, made up of members of the Arthritis and Drug Safety Advisory Committees, to review the cardiovascular safety of these arthritis pain medications.FDA Directive: Stronger Warning Labels for Some Pain MedicationsOn April 7, 2005, taking into account the recommendations of the Advisory Committee, the FDA issued the following directives: Bextra, a COX-2 specific inhibitor manufactured by Pfizer, was withdrawn from the market.All prescription NSAIDs must revise their labeling to include a black box warning that highlights the potential increased risk for cardiovascular (CV) events as well as the potentially life threatening gastrointestinal (GI) bleeding associated with these drugs. Celebrex, the only COX-2 specific inhibitor remaining on the US market, was included in this directive.All OTC NSAIDs (except aspirin) will be required to revise their labeling to include more specific information about the potential for GI and CV side effects, a stronger reminder to follow label instructions, as well as a warning about potential skin reactions.To further evaluate the potential for increased CV risk, the FDA also announced that all NSAIDs must conduct and submit to the FDA a comprehensive review and analysis of pertinent safety data from clinical trials. Aleve (naproxen sodium) is supported by clinical studies conducted to gain approval of naproxen as a prescription product and as OTC that do not provide any evidence of increased risk of cardiovascular events. Treatment Options: What Should Arthritis Patients Know?For some people who suffer from pain associated with arthritis, their symptoms can be managed with exercise, heat/cold therapy, joint protection, assistive devices, weight control, or in some severe cases, surgery. For others, medications are needed to help manage the symptoms associated with arthritis. When taken as directed OTC medications such as Aleve provide a safe and effective way to treat mild to moderate pain of minor arthritis. If patients have questions, they should consult their health care professional about which treatment option is most appropriate.Why Its Important to Treat ArthritisArthritis affects approximately 66 million Americans and is the nations leading cause of disability. There are over 100 different types of arthritis, and they all have different symptoms that vary in severity from person to person. The most common form of arthritis, osteoarthritis, is characterized by the breakdown of cartilage that causes the bones to rub together, resulting in pain, loss of movements and stiffness . Arthritis is usually a chronic condition. For more information on Aleve and naproxen, visit the Aleve website at www.aleve.com. For more information on arthritis pain relief, visit www.arthritis.org. About the Author
R.L. Fielding writes on a number of subjects.

Cooking for Special Occasions

We all have those moments in our lives when we stroke as if everything needs to be all right right. It is these moments that we often cite to as special occasions. When it comes to cooking for special occasions, many of us bonanza that we drop the ball in our anticipation and feel as though we have ruined the spell. While this is often far from the truth, it does serve to diminish the moment in many of our minds. For this reason, you need to work up a repertoire, if you will, of simple to make special occasion cooking recipes.

You will be shocked and amazed at all the sinfully rich and delicious meals and side dishes that are out there, that are amazingly quick and easy to prepare. This means that you bequeath not run the all too commonplace disaster scenarios that you hear about and will still manage to have a wonderful meal that is enjoyed by all.

The trick is in choosing a rather simple goodies dish and dressing it up with the more decadent side dishes. Incredibly rich side dishes that are simple to prepare are greater in number than meat dishes that require little culinary effort. You should also keep in mind the audience for your special point. Sometimes a family favorite makes the instance seem immensely more special than an all out effort for chicken cordon bleu or veal Marsala. There is no point in going to an extreme effort to create a culinary masterpiece if it is going to be riddled with picky children proclaiming that they do not like this or that about your meal.

Another great idea when it comes to cooking for special occasions is to prepare as much as hidden ahead of time in order to alleviate the affliction during the event and to allow you more time to funk the event rather than dealing with the details of meal preparation. The greatest gift you can really part with yourself when cooking for special occasions is the time necessary in order to enjoy these special occasions. This is not to say that ace isnt some cooking that will need to be done.

Foods that can be prepared ahead of time and reheated just brother to serving are often the best when it comes to cooking for special occasions. Able are all kinds of appetizers, entrees, and desserts that will work perfectly in this particular instance. You can often find them by performing a mild Google search online or by sorting through many of your favorite cookbooks at homely. The important thing is that you do not get so caught up in the idea of cooking for special occasions that you forget to actually enjoy the occasion.

If this is not the way you prefer to make things that is perfectly understandable. Some of us do thrive in high stress situations. The key for those who prefer to do all the entree preparation when cooking for special occasions at the time of cooking is construction properly and allowing plenty of time for possible hiccups in the process. Mistakes occur when people feel rushed and hurried in their culinary efforts.

Too many common mistake that is made when cooking for special occasions is cooking outside of your comfort zone. When you are preparing a challenging recipe it is best if you do this during a time when you are not going through the stress of potential visitors or insuring the foremost possible of circumstances. In other words, it is best to challenge your culinary talents when you do not have a vested interest in success.

Special occasions are a great time for friends and family. The hope is that you will have many special occasions throughout your life. Do not squander too much extent and energy fretting over cooking for special occasions. Instead, put all of your effort into enjoying those occasions.

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Why Do We Develop High Blood Pressure?

You might wonder why you and everyone else develop high blood pressure. While you might develop it you can easily lower or control it. The best way to prevent developing it is to keep a close eye on it from the beginning.

Older adults may be more prone to developing high blood pressure but if you start at a young age you can prevent it easier. There are a few things you want to watch for that cause high blood pressure. This is why we develop high blood pressure because we are not aware of what is causing it.

Weight plays a major role in developing high blood pressure. Overweight people are more likely to develop high blood pressure but do not be discouraged. Losing as little as ten pounds can help your blood pressure significantly.

Once you lose a measly ten pounds just imagine how much easier it will be to lose even more. A great way to keep losing and maintain a healthy weight is by a healthy diet. Your diet factors in to developing high blood pressure as well.

High amounts of salt and sodium intake can cause high blood pressure. Try to limit your meals on salt and opt for other seasonings instead. There is a wide variety of seasonings available so you are sure to find something you really like.

Also try to incorporate fresh fruits and vegetables into your diet. Eating more of these will help your blood pressure not to mention you will feel healthier as well.

Do you use tobacco or drink large amounts of alcohol? If so, this could be why you have developed high blood pressure. Both of these can raise your blood pressure so if possible try to quit or at least cut back on your use and consumption. This will significantly help lower or maintain a normal level of blood pressure.

African Americans are more prone to develop high blood pressure. It starts at an early age and can be more severe. African Americans also have a higher death rate from kidney disease and stroke than white Americans. Even so, you can still treat high blood pressure effectively.

Do you exercise regularly? If not you might be at risk for developing high blood pressure than those that do regular exercise. Luckily you can easily fix this by doing physical activity for at least thirty minutes a day. You might say, “I don’t have thirty minutes a day to set aside.” While you may not have thirty minutes all at once to set aside, you could probably find it easier to set aside ten minutes at a time.

If you find yourself stressed very easily over anything and everything you could easily develop high blood pressure. Yes, stress is a factor of high blood pressure. Stress is very common for many people but easily treatable. Is there something you enjoy doing that relaxes you?

Consider picking up a hobby that you find relaxing and lets you de-stress. Do this whenever you feel stressed to the max and do it often. Keeping your stress level low will help keep your blood pressure low as well.

Last but not least, certain medications can cause you to develop high blood pressure. Are you on medications? You might consider talking with your doctor about their side effects and if they cause high blood pressure. Every time you start a new medication you want to ask your doctor about this.

It is never too late to take better care of your health so consider starting today. Keeping control of your blood pressure will help lower your risk of a stroke or heart and kidney disease. Talk with your doctor about any concerns or ask any questions you might have.

Who Can Develop High Blood Pressure?

Are you battling high blood pressure? Do you feel like you are the only one? You shouldn’t feel that way because millions of Americans have high blood pressure. Only a certain percentage of them actually know it.

When you see your doctor you have your blood pressure checked. Some people think this is irrelevant because they say they will never have high blood pressure. Probably one of the reasons so many people do not even know they have it. They think for whatever reason it won’t happen to them.

While it can be frustrating to monitor your blood pressure, there are things you can do to help lower it or keep it under control. Exercise is a great way to lower and control your blood pressure.

Close to one in three American adults have high blood pressure. While high blood pressure is very common among Americans, African Americans tend to get it while they are young and more often than white Americans.

Whatever your age or gender or ethnicity, you can easily prevent and control your high blood pressure. There are simple ways like exercising and even simple lifestyle changes to do this.

If you are over weight you are at a greater risk of high blood pressure. The higher your blood pressure is the higher your risk of stroke or heart disease is. Exercising can help you lose weight and also lower your blood pressure.

Eating healthy is also a great way to control blood pressure. Eating the right fruits and vegetables and foods altogether is proven very beneficial. Using less salt and sodium makes a huge difference and also drinking very minimal alcohol.

Tobacco also increases blood pressure, so if you smoke or use any kind of tobacco product, consider limiting yourself if not quitting altogether. You may find it easier to slowly wean yourself from it.

Stresses plays a major factor in blood pressure and let’s admit it, everyone gets stressed at one time or another. If you find yourself dealing with a large amount of stress, you should try some relaxation techniques. Consider meditation, or whatever it is that relaxes you. Do this when needed and you will see a significant improvement in the way you feel.

Did you know the cause of ninety to ninety-five percent of high blood pressure is unknown? Luckily high blood pressure can be easily detected and controlled with multiple options.

Another interesting statistic shows that people with less educational and even income levels usually have higher blood pressure. Do you wonder why this? Maybe a lot of that is stress!

It doesn’t really matter who can develop high blood pressure, it’s controlling it that matters. If you are battling high blood pressure or just want to take necessary precautions to help prevent from getting it, see your doctor. Ask any and all questions and they can help you find a great effective way to lower or control your blood pressure.

Remember to exercise and try to eat healthier. These overall will work wonders and you can thank yourself in the end when your body does.