Tag: strain

In Dire Need of Swine Flu Vaccine

According to the World Health Organization, efforts for developing a swine flu vaccine has been ongoing since the first human case of the virus has been confirmed. Estimates place the initial doses of the vaccine will be administered in 5 to 6 months time.

While people diagnosed with H1N1 virus seems to be headed for recovery, there have been deaths recorded. Aside from that, receiving vaccines for this virus is important particularly the elderly and individuals with a weak immune system, since they are prone to complications such as pneumonia.

Likewise, the vaccine will serve as protection in case the condition persists particularly during the winter months which is the time when influenza is at its peak.

According to the World Health Organization (WHO), although they are still incomplete, current evidence shows that seasonal influenza vaccines will provide minimal or no protection against swine flu. Every year, a new batch of flu vaccine is developed and matched with strains that the WHO determines will most probably circulate in the winter months, which happens to be the peak season for influenza outbreaks.

Influenza virus comes in various strains which contains different proteins on their surfaces. The body’s immune system can only fight and destroy a virus if they are able to recognize these proteins. It is worth noting that antibodies that recognize one strain may not detect other strains.
Existing vaccines may only offer some protection against swine influenza if the proteins on its surface are identical to strains used to develop previous vaccines. According to the NIBSC, they are trying to determine if the swine flu virus, which is an H1N1 strain of type A influenza, as well as previous H1N1 vaccines match current vaccines.

The preparation of a vaccine commences after a virus develops as they provide the starting point for the production of the vaccine. As such, there is always a time delay while a vaccine is being developed. Preparation of a vaccine involves several steps so it would take several months before a vaccine becomes available.

According to WHO estimates, the virus needed for producing the vaccine will be accessible to vaccine manufacturers by the middle of May while the initial dose for a new vaccine would be ready within 5 to 6 months after that. Waiting time would be much longer if the growth of the vaccine proceeds rapidly.

Vaccination plays a crucial role in the prevention and reduction of the effects of serious conditions. Unfortunately, they are not entirely effective and could lose its effectiveness if the virus mutates.
Existing flu vaccines are valid for about one year and are 70% – 80% effective against transmission with strains of influenza virus that are identical to strains used in the production of vaccines.

The WHO believes that it is too early to tell how the A(H1N1) virus would change. It is closely monitoring any changes in the virus and this would help countries quickly react to any important changes that the virus may show.

Vaccines help the body combat certain diseases in case an individual becomes afflicted with the illness in the future. On the other hand, an antiviral drug is used on people who is already infected with a virus. Although they work in various ways, they generally work to prevent the virus from spreading to different cells in the body.

Swine flu vaccines are administered prior to exposure to a virus so they would be protected from that agent. Antivirals only work if administered within a certain period of time before or after they are exposed to the virus.

Vaccinations of Swine Flu

Vaccine against seasonal influenza strain H1N1 is not believed to protect us. Vaccines against the Swine Flu to cope with seasonal flu to minimize infection rates are typically developed, and yet annually it still kills around half a million of the worlds population. Today, they use an injection of “killed virus”, the worlds flu vaccines. Manufacturers are asked to produce a vaccine for H1N1, they are unlikely to be able to respond quickly enough if a global pandemic is declared.

About a billion doses of any one vaccine each year is the only they can produce, so that even if all the capacity was switched to fight a pandemic flu, as opposed to a seasonal flu. Few years ago, the supply of the vaccines they have produced were enough to epidemic but now is not enough for the total populations outbreak.

Deadlier wave of a new H1N1 strain they forecast will reappear this fall and they have to produce pandemic vaccines as early as now to prepare for a turn out as the vaccine may not be as effective will be sure to a big waste of resources with serious results, and there would also be a shortage of seasonal flu vaccine available. Only a few more weeks were needed for the World Health Organization (WHO) and Centers for Disease Control and Prevention) CDC to develop a “seed strain” of the pandemic virus on the first days May, but producers would then need four to six months before they could create large volumes of vaccine.

In other point of view, the WHO will attempt to make sure that a substantial amount is available and should a pandemic be declared and a vaccine produced, for the benefit of developing countries. Vaccine manufacturers and countries with standing orders, such as the U.S. and some European countries will be asked to share with developing countries from the moment the first batches are ready if an H1N1 vaccine is made.

2009-2010 flu seasons are ineffective against the new strain with the previous influenza vaccines for the north and south hemispheres. The WHO claims that two separate immunizations will be required for seasonal and swine flu, but no decision would be made on whether to begin producing a swine flu vaccine. The board will receive inputs from manufacturers (e.g. GlaxoSmithKline, Sanofi-Aventis, Novartis and Baxter International) regarding when they are able to finish manufacturing the seasonal shot and begin production of the swine flu vaccine, waiting from the WHO of their recommendations and “seed virus”, and some may be ready to proceed with production at that time.

There also antiviral drugs available for treatments of influenza, the virus is resistant to amantadine and rimantadine but sensitive to the oseltamivir and zanamivir. There remains concern that this strain may mutate develop resistance to oseltamivir in the future. For the treatment and prevention of the Swine Flu, the CDC recommended the use of Tamiflu (oseltamivir) and Relenza (zanamivir). Studies shows that the medication continues to maintain its effective that why the U.S. government had already extended the shelf life of federally stockpiled Tamiflu from their original five years to seven years.

Buying medications from online sources is not recommended by the WHO because they believed that half of the drugs they sold are counterfeited. Others are thinking if they grab up antiviral drugs for their safe even if they have no symptoms, the health officials warned them may eventually lead them to the Swine Flu virus developing drug resistance.

The Latest Killer Flu: Swine Flu And You

The Center for Disease Control has probably had some very wild times this past decade. First SARS, then the bird fle, and now today’s potential epidemic is the swine flu. First manifesting itself in Mexico this past April, this new and terrible strain of Type A H1N1 influenza is one of those things that every microbiologist and health care professional is afraid of.

The reason for that fear is pretty simple. Like the bird flu, this particular strain crossed species. Specifically, it crossed over from the swine population, a species that has an in-built resistance to it, to the human population, a population that does not. If this spreads and becomes a full blown epidemic, the swine flu may reach the heights of the 1918 Spanish Flu, which killed fifty to a hundred million people worldwide and devastated the post-World War I generation.

The CDC has stepped up its alert levels and some governments have instituted quarantine procedures, but still more and more cases are emerging across the world. Mexico City has most of the fatalities though, with most other cases outside of city being less severe in symptoms. However, this is just a month into the outbreak and anything can still happen. With the continuing spread of the disease, let’s talk about how this affects you.

Let’s be honest here, after all that I’ve just said, there’s actually no real reason to panic. Actually, we shouldn’t panic. That’s because panic just confuses people and to deal effectively with something of this magnitude, being confused is not the state of mind you want to be in. What you really need to be is to be aware and knowledgeable about what you’re dealing with. This and quick ddecisive action is what got the world through SARS and the bird flu, and it most likely will help us make sure that the swine flu isn’t the one that kills us all.

The swine flu is pretty much like your normal human flu. It has all the same infection vectors, all the same symptoms, and all the same treatments. It’s all just heightened by a factor of two, mostly because humans haven’t any natural resistance to the disease. If you want to avoid getting infected do all the same things that you’d do to avoid getting the flu: wash your hands regularly, take your vitamins, and avoid sick people.

If you somehow get sick, it’s not the time to run around like a headless chicken. You immediately isolate yourself so you won’t infect others and observe your symptoms, all of the while taking your regular flu medicine. Note that even if it is called swine flu, it’s still a virus and antiviral drugs are pretty effective in putting a dent in the symptoms you may experience and help your immune system kick the infection out.

It your symptoms persist despite your efforts, you better start calling for a doctor. Don’t worry if it really is the swine flu – the CDC has recommended the use of antiviral inhibitors that help stop the reproduction of the disease and the sickness is definitely treatable.

Let’s all just remember that the swine flu maybe deadly, but it’s still just a disease. And the only things you need to have to beat a disease is being smart and being careful. With all the noise that the media brings up about it, that fact may get lost in the shuffle. Remember it and it may just save your life.

What Evidence of Congestive Heart Failure is a Diagnosis Based

What Evidence of Congestive Heart Failure is a Diagnosis Based on?

While all cardiac conditions carry similar symptoms of chest pain and difficulty breathing, congestive heart failure generally presents with a very specific set of symptoms and lab results, giving doctors a very firm set of clues upon which to base a definite diagnosis.

Dyspnea, or difficulty breathing, coupled with severe pitting edema (when the body retains fluid to the point of holding the imprint of an object that is pressed into the skin for several minutes) are generally the first pieces of evidence pointing to congestive heart failure. Heart failure results in the heart not being able to efficiently pump blood throughout the body; as a result, fluid accumulates rather than being excreted and causes the body to swell as if it were a water balloon. Non-pitting edema, or fluid retention that does not hold an imprint, is not caused by heart failure and indicates that another diagnosis needs to be made. The patient may produce a frothy pink sputum when they cough.

In addition to the symptoms related to the fluid accumulation general weakness and malaise, particularly during times of physical exertion are frequent complaints of patients suffering from congestive heart failure, and should not be ignored. This is caused by a lack of nutrients and oxygen from the blood to the body tissues, and may result in permanent damage to the organs if they are left without these vital elements for a prolonged period of time. Anuria, or a lack of urination, is also evidential of heart failure as fluid accumulates in the tissues rather than being properly excreted. Patients may suffer from a changed mental status due to toxins accumulating in the body.

Once the physician suspects heart failure based on the physical evidence, blood samples will be sent to the laboratory. Beta-natriuretic peptide, or BNP, is an excellent screening tool in suspected cases of heart failure. This hormone is produced in greater quantities by the failing heart muscle as fluid levels rise, with a level between one hundred and five hundred pg/mg suggesting congestive heart failure and greater than five hundred being fairly diagnostic; however, an elevated BNP should not be considered to be sufficient evidence upon which to base a positive diagnosis, as conditions such as renal failure, ventricular strain, tumors or hypoxia can also cause BNP levels to rise. Arterial blood gases may be tested to determine the degree of hypoxemia. A decreased erythrocyte sedimentation rate, proteinuria (protein in the urine), and a mild azotemia (elevated blood urea level) can be seen in early to moderate disease. An increased serum creatinine, hyperbilirubinemia (increased bilirubin in the blood) and dilutional hyponatremia (decreased serum sodium levels) are evidence the patient is suffering from a more advanced case of heart failure.

Radiology will also wish to perform imaging studies to evaluate the condition of the heart. A chest x-ray will generally reveal cardiomegaly (enlargement of the heart) and pleural effusion (fluid around the heart). An echocardiogram may be performed to evaluate the internal structures of the heart to evaluate for any structural abnormalities, as in the case of mitral stenosis. This provides evidence to determine the underlying cause of congestive heart failure, particularly in suspected cases of valvular heart disease.

Physicians are like detectives, if you will. Once these tests have all been run they will gather these pieces of evidence together and put them together to form a fairly accurate picture of the patient’s condition, allowing for an accurate diagnosis leading to proper treatment.