Tag: Novartis

Swine Flu Vaccine Close To Reality According to Experts

Officials of the Federal government believe that the swine flu vaccine that would protect all Americans from future H1N1 outbreaks would be available by January or late November at the earliest.

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wever, countries outside the United States and other nations that manufacture vaccines would take several years to generate sufficient vaccines to meet global demands.

Although manufacturing of the vaccine is faster than it was a few years back, it may still not be enough to prevent death and illness if the dreaded virus begins to spread and becomes virulent, experts predict.

In the United States, the main obstacle despite long years of effort remains to be the 50-year old technology they use in manufacturing flu vaccines. The Federal government had invested time and billions of dollars shifting to a quicker and more reliable method.

One such procedure involves cultivating the vaccine viruses in vats of cells instead of hen’s eggs. There are several small companies that are developing new methods that would pave the way for the creation of large volumes of vaccines in a span of weeks.

Dr. Greg Poland, who is the head of the vaccine research program at the Mayo Clinic, admits that the cell-based cultivation technology is not yet available while the never technologies have not yet been proven to satisfy most experts.

In addition, government officials have also not yet decided on whether or not H1N1 is a potential risk that demands production of vaccine. However, they are implementing the initial steps. Andrin Oswald, Chief Executive of the Vaccine Division of Novartis, revealed that one possible problem would be the manufacture of vaccines for swine influenza could hamper the production of seasonal flu vaccines for the coming winter. The most likely thing to do is to compromise, according to Oswald.

However, Robin Robinson, who manages the Emergency Preparation Research Program of the Department of Health and Human Services, believes that majority of manufacturing efforts of vaccine makers would have been completed by June.

According to Dr. Robinson, if the manufacture of the H1N1 vaccine would commence after that, the first 50 million to 80 million would be ready by September.

Dr. Robinson continued by saying that the entire 600 million doses, which are sufficient to give the required two shots for every American would be available by January. Adding the immune stimulant adjuvant to the vaccine could greatly reduce the required dosage, paving the way for the availability of the doses by the latter part of November.

The vaccine industry in the country is now very much capable of responding to the outbreak than it was five years back, when there were only two vaccine manufacturers and encountered a severe shortage. At present, there are five manufacturers supplying vaccines to the domestic market. The vaccine industry, which is used to be the backwater of the pharmaceutical industry, is generating new investments, as a result of government subsidies and higher cost for vaccines.

Despite of this, a World Health Organization and International Federation of Pharmaceutical Manufacturers and Associations revealed that it would still require four more years of manufacturing to meet global demands for a vaccine that would provide protection against bird flu strain that has been the major concern of health officials over the last few years.

Finally, the Federal government is encouraging manufacturers to shift their production in the United States, since all except Sanofi Aventis is now importing swine flu vaccines.

Vaccinations of Swine Flu

Vaccine against seasonal influenza strain H1N1 is not believed to protect us. Vaccines against the Swine Flu to cope with seasonal flu to minimize infection rates are typically developed, and yet annually it still kills around half a million of the worlds population. Today, they use an injection of “killed virus”, the worlds flu vaccines. Manufacturers are asked to produce a vaccine for H1N1, they are unlikely to be able to respond quickly enough if a global pandemic is declared.

About a billion doses of any one vaccine each year is the only they can produce, so that even if all the capacity was switched to fight a pandemic flu, as opposed to a seasonal flu. Few years ago, the supply of the vaccines they have produced were enough to epidemic but now is not enough for the total populations outbreak.

Deadlier wave of a new H1N1 strain they forecast will reappear this fall and they have to produce pandemic vaccines as early as now to prepare for a turn out as the vaccine may not be as effective will be sure to a big waste of resources with serious results, and there would also be a shortage of seasonal flu vaccine available. Only a few more weeks were needed for the World Health Organization (WHO) and Centers for Disease Control and Prevention) CDC to develop a “seed strain” of the pandemic virus on the first days May, but producers would then need four to six months before they could create large volumes of vaccine.

In other point of view, the WHO will attempt to make sure that a substantial amount is available and should a pandemic be declared and a vaccine produced, for the benefit of developing countries. Vaccine manufacturers and countries with standing orders, such as the U.S. and some European countries will be asked to share with developing countries from the moment the first batches are ready if an H1N1 vaccine is made.

2009-2010 flu seasons are ineffective against the new strain with the previous influenza vaccines for the north and south hemispheres. The WHO claims that two separate immunizations will be required for seasonal and swine flu, but no decision would be made on whether to begin producing a swine flu vaccine. The board will receive inputs from manufacturers (e.g. GlaxoSmithKline, Sanofi-Aventis, Novartis and Baxter International) regarding when they are able to finish manufacturing the seasonal shot and begin production of the swine flu vaccine, waiting from the WHO of their recommendations and “seed virus”, and some may be ready to proceed with production at that time.

There also antiviral drugs available for treatments of influenza, the virus is resistant to amantadine and rimantadine but sensitive to the oseltamivir and zanamivir. There remains concern that this strain may mutate develop resistance to oseltamivir in the future. For the treatment and prevention of the Swine Flu, the CDC recommended the use of Tamiflu (oseltamivir) and Relenza (zanamivir). Studies shows that the medication continues to maintain its effective that why the U.S. government had already extended the shelf life of federally stockpiled Tamiflu from their original five years to seven years.

Buying medications from online sources is not recommended by the WHO because they believed that half of the drugs they sold are counterfeited. Others are thinking if they grab up antiviral drugs for their safe even if they have no symptoms, the health officials warned them may eventually lead them to the Swine Flu virus developing drug resistance.