Tag: Liver Cells

Connecting Liver Disease And Gilbert’s Disease

The human liver is one of the most important organs of the body. It is responsible for cleaning our internal organs of the entire gunk and bile that is deposited by a person on a regular basis. But conditions like Gilberts disease and other forms of liver disease makes our livers weak and prone to breaking down.

To understand better how the liver is affected by different kinds of diseases and the impact of these conditions to our body. Liver disease is a general term used in describing any kind of sickness affecting the liver. Many of theses conditions are accompanied by jaundice caused by the heightened levels of bilirubin in the system. The bilirubin is the product of the breakup of the hemoglobin of dead red blood cells; usually, the liver takes away bilirubin from the blood and excretes it through bile.

The following are some of the known conditions that are considered as liver diseases:

– Hepatitis. This is the inflammation of the liver. This caused mainly by different kinds of viruses, there are also times that it is caused by some poisons, even hereditary conditions.

– Cirrhosis. This is the formation of fibrous tissue in the liver, the fibrous tissue takes the place of dead liver cells.

– Haemochromatosis. This is a hereditary disease caused by too much iron in the body causing liver damage.

– Cancer of the liver. This is usually coming from other parts of the body that is also affected by cancer. Usually, when cancer cells metastasis, it reaches the liver and it starts spreading from there.

– Wilsons disease. This condition is hereditary and copper deposits in the body cause it.

– Budd-Chiari syndrome. This is caused by the obstruction of the persons hepatic vein.

– Gilberts syndrome. This is a genetic disorder of bilirubin metabolism, found in about 5 percent of the population.

– Glycogen storage disease type II. Here, the build-up of glycogen causes progressive tissue weakness (myopathy) throughout the body and affects various body tissues, particularly in the heart, skeletal muscles, liver and nervous system.

There are also many pediatric liver diseases, including biliary atresia, alpha-1 antitrypsin deficiency, alagille syndrome, and progressive familial intrahepatic cholestasis, to name but a few.

A number of liver function tests are available to test the proper function of the liver. These test for the presence of enzymes in blood that are normally most abundant in liver tissue, metabolites or products.

Symptoms of a diseased liver

There are a few external signs that we could include to determine a diseased liver, some of those external signs are a coated tongue, bad breath, skin rashes, itchy skin, excessive sweating, offensive body odor, dark circles under the eyes, red swollen and itchy eyes, acne rosacea, brownish spots and blemishes on the skin, flushed facial appearance or excessive facial blood vessels.

There are other symptoms to look out for and they include jaundice, dark urine, pale stool, bone loss, easy bleeding, itching, small, spider-like blood vessels visible in the skin, enlarged spleen, fluid in the abdominal cavity, chills, pain from the biliary tract or pancrea, and an enlarged gallbladder.

The improper digestion and absorption of fats may lead to symptoms that include indigestion, reflux, hemorrhoids, gall stones, intolerance to fatty foods, intolerance to alcohol, nausea and vomiting attacks, abdominal bloating, and constipation. Unfortunately, some liver diseases like Gilberts disease are known to share symptoms with other liver diseases. So its better to consult a professional.

What You need To Know About Gilbert’s Disease

There are quite a number in the American population that had been affected since their time of birth by this condition, Gilberts disease affects about two to five percent of the population in the United States alone. To better understand what it is and how it affects the people ridden with the condition, here are some of the frequently asked questions about Gilberts disease.

1. What is Gilberts disease? Gilberts disease is known to be one of the causes of mild jaundice once in a while. It is typically not dangerous and has no need for treatment. It is due to a condensed amount of a compounds in the liver, which processes a breakdown result of blood cells called bilirubin. Gilberts disease is a condition wherein the liver has a problem in breaking down the bilirubin completely.

2. Where did the name Gilberts disease came from? In 1901, a French gastroenterologist named Augustin Nicolas Gilbert and his co-workers described the differences in the symptoms of Gilberts disease and the other liver diseases. He also provided additional information on how to acquire it and its further transmission.

3. What is bilirubin and what happens to a person with Gilberts disease? Bilirubin is continuously made inside our bodies, it is a form of end product. It is the waste product of hemoglobin. Hemoglobin is a compound that is found in every persons red blood cells and it is responsible for carrying oxygen to the other cells in the body. Many of the red blood cells that we have and the hemoglobin break down each day and as a result bilirubin needs constant disposal. Bilirubin get carried to the bloodstream and into the liver where it is taken in by liver cells. The liver breaks down the bilirubin further into the gut and to bile. An enzyme or a chemical compound that can be found in liver cells called urodine diphosphate glucuronosyltransferase (UGT) aides the liver cells to break down the bilirubin. People with Gilberts syndrome have a reduced level of UGT and so bilirubin can build up in the bloodstream. High levels of bilirubin in the blood causes jaundice.

4. Who gets Gilberts disease? Gilberts syndrome is a very common hereditary condition that means there is no way to prevent or to treat the condition was it has been passed on to the next generation. About 1 in 20 people have this syndrome – but most will not be aware of it. It is more common in men than women. It is often first diagnosed in the late teens or early twenties.

5. What are the symptoms of Gilberts disease? More often than not, none. Unfortunately, the specific symptoms related to Gilberts disease is not as easy to spot and monitor like in other diseases. Gilberts disease can be very dormant in terms of symptoms that it can manifest in a person for several years with them knowing it.

6. How different is it from jaundice? Jaundice is caused by the excessive levels of bilirubin in the body, more specifically the blood. Because people with Gilberts disease have fluctuating levels of UGT or urodine diphosphate glucuronosyltransferase, the build up and the manifestation of Jaundice cant really be used to gauge the severity of a person with Gilberts diseases condition. Aside from the discomfort and stomach pains most of the other signs of having Gilberts disease can be associated with other conditions.

The Relationship Of Gilbert’s Disease And Jaundice

Unpopular diseases such as Gilberts disease can be alarming once you are diagnosed with it because you will never know what will happen to you. Upon hearing that you are or you might be suffering from it, it can be hard to accept it because you dont know what to do.

To ease the burden that people with Gilberts disease, doctors try to explain everything about the condition in laymans terms. And one of the easiest ways to understand it is if it is compared to more common diseases that have similarities in it like jaundice.

What Gilberts disease is all about

Gilberts disease was first described by a French gastroenterologist names Augustin Nicolas Gilbert in 1901. Gilberts disease is an asymptomatic (no external symptoms) condition affecting the liver. The condition affect an enzyme in the body called urodine diphosphate glucuronosyltransferase or UGT (abbreviation). UGT aids the liver in breaking down bilirubin which is found also in the blood stream.

Bilirubin is the waste product of the hemoglobin in the blood. Hemoglobin is found in the red blood cells that carry oxygen to other cells in the body to complete the cycle of respiration. After the red blood cells successfully brought the oxygen to the other parts of the body, the blood produces bilirubin. The liver cells then collect all the bilirubin produced by the blood, transfer it to the liver to be broken down into the gut, and turned to bile.

This is where UGT or urodine diphosphate glucuronosyltransferase comes in, it helps the liver cells process the bilirubin in to bile. Gilberts disease affects the production of UGT, this is because it fluctuates the production of UGT in the body. The fluctuating levels of UGT greatly affect the levels of bilirubin retained in the blood. Bilirubin is orangey- yellow in color, which in turn causes a patient to have jaundiced skin.

What is jaundice?

Jaundice is the condition of the blood that has external manifestations. The two most common manifestation of Jaundice is the yellowing of the skin and in the white of the eyes. Jaundice if one of the most common symptoms or manifestations of different liver diseases and sometimes it may be the cause of some discomfort among patients. The heightened bilirubin stores in the body and in the bloodstream causes jaundice but it usually has no serious effects and it can occur in people more than once in their entire lifetime. Mild jaundice is not always caused by diseases of the liver there are times when it may happen under conditions of over exertion, long term stress, intense fasting, and other bodily infections, but the condition is otherwise shows no external manifestations.

It happens when there is a flaw in the liver that averts from removing bilirubin from the blood, to be converted to glucuronic acid (conjugated) or excreted in bile in this case if the person has Gilberts disease.

Lastly, when there is obstruction of the bile ducts that reduces the stream of bile and bilirubin from the liver into the guts. The decreased conjugation, emission, or gush of bile that can result in jaundice refers to cholestasis: however, cholestasis does not always effect in jaundice.

Jaundice or cholestasis, by themselves, causes just a few problems (excluding the conditions of newborns, and jaundice in this case in newborns is different from most other types of jaundice.) Jaundice can make the skin and the whites of the eyes look sclera yellow. As well, stool can turn out to be light in color, even clay-colored because of the lack of bilirubin that usually gives stool its brown color. The urine may become dark or brownish in color. This takes place when the bilirubin that is building up in the blood starts to be excreted from the body in the urine.

Other than those scenarios there is not much to worry about if you have Gilberts disease, you may experience a jaundiced appearance but you can still enjoy a healthy life.