Tag: Estradiol

How Much is Too Much Estrogen

Through out the years, estrogen has caused so much fuss and controversy in the medical arena.

Many scientific studies were launched regarding its beneficial result as well as its adverse effect in the human body.

Despite its popularity in the market and in the scientific field for curing and preventing various kinds of illness and other afflictions, many issues still abound regarding its very nature.

Along side these issues were countless questions that continue to bewilder many people, one of the most frequently asked question regarding estrogen is how much is too much.

Does this compound, which has been proven to have medical benefits cause adverse effect when taken beyond adequate amount?

According to the recent findings of Womens Health Initiative in 2004, the daily-recommended intake of estrogen is highly dependent on the preparation used and to the brand name of the chosen estrogen alternative.

For instance, when a person is using conjugated estrogen, which is commonly used in the United States and falls under the brand name of Premarin, and Cenestine the sufficient intake should fall from .3 to .625 mg/ day.

The dosage is entirely different when the person is taking estrogen prepared by using synthetic Estradiol and the brand name is Estrace, research showed that adequate dosage is from .5 to 1 mg/day.

While the brand names Estretab and Menest works effectively when the person intakes .3 to .625 mg/ day under Estrified preparations, while a lower dosage is recommended for those who take ogen estrogen the ample amount for this brand ranges from .6 to .125 mg/day.

In the case of those who take Estraderm, Vivelle, Climera the finding suggests that .02 to .05 mg/ day be taken when transdermal preparation is used, while the Menostar estrogen brand has the lowest dosage with the required daily intake of only .014 mg/ day.

Since the matter of decision-making is relatively dependent on individual basis, rather than taking into consideration age groups and related cases.

It is recommended that each individual needs to be evaluated first on their health history to advise the most appropriate estrogen treatment and other necessary preparations.

Aside from this, other factors are taken into consideration in planning the estrogen therapy for each individual case.

Part of the related study undertaken by the group regarding too much estrogen intake, showed various negative effects on the body which will manifest in the duration of short term and long term intake.

The negative effects for short-term intake over dosage are:

Breast tenderness
Vaginal Bleeding or spotting
Enlarged Fibroids
Migraine and headaches
Abdominal pain and Bloating
Nausea
Skin rashes
Increase in Triglycerides
Coronary Artery Disease
Thromboplebitis

Another question resurfaces along side the inquiry regarding too much estrogen intake.

Does a woman who has been taking estrogen for quite some time, be subjected to the same daily-recommendations of intake for those who has just started the therapy?

Although the Womens Health initiative did not take in hand this particular query, observational undertakings proved that taking estrogen for quite a while starting in menopausal stage prove to have some health benefits.

Among these benefits are:

Lower hip fractures
Lower cases of heart attacks

While the negative effect for long-term intakes over dosage are:

Gall stone
Breast cancer
Endometrial cancer

The bottom line is, too much of something is bad for ones well being, even if we talking about a compound with an immense health benefit and wonders- as in the case of estrogen.

Estrogen as a Contributor in Signalling our Body Clock

As medical technology advances throughout the years, there has been much fuss in the medical field about estrogen.

Many studies and researches were conducted towards finding out the very nature of estrogen.

All of these undertakings agreed on one thing, estrogen is a primary component in the indication of the human body clock. It was found that it directly relates in the body cycle of a human being.

Estrogen, as defined in the modern medical dictionary- does not only pertain to a single compound but is rather made up of groups of steroid compounds.

While it is present in both male and female, it has higher concentrations in female, because it is the one responsible for the promoting of female secondary characteristics.

This includes breast development, and it is an important hormone that helps in promoting sexual vitality, relieving hot flashes, night sweats and other deficiency symptoms that go along with old age.

The female body produces three major types of this estrogen, these includes estriol, estradiol, and estrone.

Estriol is found to be the weakest among the three estrogens. Its high level of existence in the body denotes a less likely possibility of developing breast cancer.

As mentioned in the American Medical Journal Association dated in 1966, according to Dr. H.M. Lemmon, M.D. there is a higher concentration of this particular substance in the body of those women who does not have breast cancer.

It is very beneficial to the vagina, vulva and cervix. In cases where there is a related affliction to the mentioned parts, it is safest if the patient is going to use Estriol Estrogen preparation.

Estradiol is known to be the principal estrogen, it is helpful in carrying out reproductive functions and is produced in the ovaries. Because it is stronger than Estriol it is more effective symptomatic alternative than the latter.

Estrone on the other hand has the same function as the Estradiol, but it is considered to have a weaker effect.

The pituitary gland and the hypothalamus is the one responsible for producing these types of hormones, and acts as the lutienizing agent in controlling its production in the body.

As the menopausal stage occurs, it is usually characterized by a full year without menstrual period and the level of estrogen in the body gradually goes down. Decrease in egg production, low level of sexual desires, lower bone density and muscle firmness as well as skin integrity follows.

As the estrogen production starts to diminish in the menopausal period, this marks the transgression of the human cycle.

Lastly, this ultimately signals the descent of the human body clock as determined by the particular hormone-estrogen.