Tag: Alzheimer’s

Alzheimer’s Testing

Alzheimer’s is a disease that robs millions of people each year of their memories, their personalities, and the ability to complete daily activities. The disease can greatly affect the quality of life of every sufferer as well as those people around him, most especially immediate family members.

For a long time, most people believe that there is nothing that could be done to prevent this awful disease. People came to accept it as a result of deteriorating of mental abilities due to age. It was considered as simply something that people had to cope up with when approaching their golden years of life. But doctors today have discovered and now consider Alzheimer’s as a disease that can be treated up to a certain extent.

The hallmark sign associated with Alzheimer’s disease is the gradual loss of memory especially in people of 65 years and older. Although forgetfulness is a sign of the said disease, it should also be noted that there are other signs that may also indicate the onset of this ailment. Before coming up with your own conclusions, it is best to know more about Alzheimer’s through its exhibited signs, how it can be diagnosed and how it will eventually affects the sufferer.

Diagnosis of Alzheimer’s disease can be done through a series of tests. The patient exhibiting some signs of the disease must undergo a variety of laboratory tests, such as physical and mental assessments. As of late, there is no known single test available that will effectively diagnose Alzheimer’s in patients.

But with recent developments and advances in the medical field, doctors have been able to devise a set of Alzheimer’s disease testing tools that can help in effectively detect symptoms of the disease in its earlier stages.

As of yet, there is no single definitive test that is able to determine if one has Alzheimer’s disease. But it is really a battery of testing that is available that makes it possible for physicians to diagnose Alzheimer’s with about 90 percent accuracy. Such battery of tests can take anywhere from one day to several weeks in order to ensure accuracy and the proper diagnosis.

Among the various tests available there is one set of tests that has recently been developed that will further help make diagnosing Alzheimer’s disease easier. A professor of psychology at Williams College in Williamstown, Massachusetts, has developed a new tool for testing called the Seven Minute Screen that can test people for the early signs of Alzheimer’s disease as well as other forms of dementia.

The said test, developed by Paul Solomon, is actually a set of four tests that can be administered to patients in just less than ten minutes, can also be completed on average of just seven minutes and forty three seconds. What makes the said test even more convenient is that it can be administered by any medical professional with just over an hour of basic training.

The short time that it takes for completing the whole test is an attractive option for doctors who may not have the luxury of time when they are diagnosing patients with Alzheimer’s.

This type of test is just a part of a much larger effort by medical researchers to develop better ways of detecting Alzheimer’s early. A likely option that some researchers are trying to look into is the use of brain scanning technology such as magnetic resonance imaging or MRI to identify even the smallest damage to the brain before any impairment in cognitive ability ever show up in people likely to develop Alzheimer’s. Other possible approaches being studied involve looking for gene abnormalities in patients that have been linked to Alzheimer’s disease.

Who are you? Alzheimer’s symptoms

From the German psychiatrist who first diagnosed the disease, Alzheimer’s is a fatal disease that has both no known cause and cure. There are treatments that help prevent the disease to develop into its complete form. Plus medications already exists which could assist patients to manage their agitation, depression, hallucinations or delusions which could manifest during the later stages of the disease.

There are a number of symptoms which help diagnose the disease. The most prominent of which is memory loss. What seems to be a simple lapse in memory could be the start of Alzheimer’s disease. Loss of memory in Alzheimer’s is manifested from the more than unusual fluctuating forgetfulness to short-term memory loss.

Later, the patient will start to forget familiar things and well-known skills. They will start to forget names, objects, and persons even those that are close to them. Alzheimer’s memory loss is often accompanied by aphasia, disorientation and disinhibition. Aside from forgetfulness and amnesia, some refer to Alzheimer’s related memory loss as memory decay, memory decline, or memory impairment (Loring, 1999).

One, however, should not conclude that all memory loss is caused by Alzheimer’s disease. There are two basic causes of memory loss, namely normal or age related memory loss and the abnormal type. It is normal that middle age and older people begin to forget a number of things. Their ability to remember is often times measured on a standardized scale.

If their memory scores fall within the designated cutoff, their memory loss is due to normal and age-related causes. Meanwhile, if they fail to pass the scores it means that their memory loss is caused by not mere age-related reasons but by abnormal, or age-inappropriate, memory disease or impairment instead. One, therefore, needs to let professional medical workers to isolate and determine if he/she got Alzheimer’s disease.

Aside from the early symptom of memory loss, Alzheimer’s disease at the early stage could also change the patient’s behavior. And as the disease develops, the patient will loose more and more control over body functions such as affecting the way the person thinks and respond. With the effects on the brain’s cognitive functions, the patient will have trouble talking, will find skilled movements troublesome to do and hard to accomplish, and will start slowing down in terms of movements.

The patient will become indecisive and will start having trouble in decision-making processes and planning stages of human activities. These losses of memory and cognitive functions are related to the frontal and temporal lobes of the brain. The two lobes are becoming disconnected from the limbic system due to the disease.

Also, part of the symptoms of Alzheimer’s is mood swings and outbursts of violence or excessive passivity. The later stages will be more horrible. People with Alzheimer’s will later on start to loose bowel movement as well as muscle control and mobility. Alzheimer’s usually develops and become fatal within approximately 710 years.

Since Dr. Alzheimer diagnosed the disease in 1901, there have been a lot of medical discoveries and tons of results from research studies and medical investigations that were found to be beneficial in preventing or delaying Alzheimer’s disease.

Studies found out that exercise helps lessen the risk of contracting the disease. Scientists have found significant findings which indicate that having high blood pressure, high cholesterol, and low levels of the vitamin folate can increase one’s risk of acquiring Alzheimer’s disease.

Drugs to Fight Alzheimer’s

Although there is no known cure yet for Alzheimer’s disease, there are already a number of drugs available worldwide that can help slow down a patient’s cognitive deterioration. The main aim of these Alzheimer’s medications is to try and improve cognitive ability or the person’s capability to think, perceive, judge and recognize.

There are currently five drugs approved by the Food and Drug Administration (FDA) that can be used to treat Alzheimer’s. There is ongoing research done all the time to test the effectiveness of such medications since they do not serve as a cure-all for the disease.
These medications may not have the same effects on all patients that are suffering from Alzheimer’s. But such prescription drugs can have significant effects on some of the patients with Alzheimer’s disease and should be given consideration as a possible treatment.

The 5 FDA Approved Medications are:
Aricept
Cognex
Exelon
Razadyne
Namenda

The first four drugs listed above belong to a group of drugs known as Cholinesterase Inhibitors. They work by trying to delay the break down of a substance known as acetylcholine in the brain which helps in bridging communication between nerve cells and has an important role in a person’s memory.

Nameda on the other hand acts on another neurotransmitter called glutamate and shields the brain from then said substance which contributes to the death of brain cells in people with Alzheimer’s disease. This drug is more effective in treating moderate to severe forms of Alzheimer’s disease, improving the day to day life of the person with Alzheimer’s disease.

The most common side effects associated with the drug Nameda include dizziness, confusion, constipation, headache and skin rashes. Some patients may experience less common side effects such as tiredness, back pain, high blood pressure, insomnia, hallucinations, vomiting and occasional shortness of breath.

The drugs Aricept, Exelon and Razadyne are seen to be most effective in treating the early stages of Alzheimer’s disease. This group of prescription drugs has been shown to have some modest effect in slowing down the degeneration of a patient’s cognitive abilities.

These drugs can also help in trying to reduce certain behavioral problems usually exhibited by people suffering from Alzheimer’s. When these drugs are administered effectively on an Alzheimer’s patient, they can significantly improve one’s quality of life and more able to cope up with the disease.

Alzheimer’s patients taking these medications may experience some side effects which may not be the same for all patients. Common side effects observed in patients using the drug Aricept include nausea, vomiting, excessive tiredness, sleeping troubles and muscle cramps.

Less frequent observed side effects of the drug are headaches and dizziness with rare cases of patients suffering from anorexia, gastric or duodenal ulcers, gastro-intestinal hemorrhage, bladder overflow obstruction, liver damage, convulsions, heart problems and psychiatric disturbances while using Aricept as medication.

The usual side effects seen in using Exelon as treatment for Alzheimer’s are nausea, vomiting, weight loss, stomach upset and fatigue. Less usual side effects observed with the use of the said drug are abdominal pain, sweating, diarrhea, headaches, tremor, and psychiatric disturbances such as anxiety or depression with rare cases of patients experiencing gastro-intestinal bleeding.

The drug Cognex is used less frequently for Alzheimer’s treatment as it can cause serious liver damage to most patients. Other side effects of the drug include nausea and vomiting. Some patients may also experience some abdominal pain, sore muscles, headache, dizziness, rapid breathing, increased urination, insomnia, runny nose or mouth, swelling in legs and feet when taking Cognex. Some of the most severe side effects associated with using Cornex are liver damage, heart problems and seizures.

The common side effects often reported with the use of Razadyne are nausea, vomiting, appetite loss and weight loss. Less common are fatigue, dizziness, tremor, headaches, abdominal pain, urinary tract infection, blood in urine, runny nose. There are no serious side effects with this drug.

Alzheimer’s, not just an old man’s disease

Alzheimer’s disease, we’ve all hear of it but do we really understand the disease? According to statistics, there are about 350,000 new cases of Alzheimer’s disease diagnosed each year in the United States.

Doing the math, you could have more than 4.5 million Americans by the year 2050 that would be affected by the disease. A grimmer outlook indicates that by 2025, there will be 34 million people worldwide Alzheimers disease.

Let’s tackle the issue step by step. Alzheimer’s disease is a known brain disorder that is progressive and irreversible. It is still not known where and how the disorder develops in the human brain neither is there any sure fire cure for the disease. What is known by medical scientists is that the disease attacks slowly.

It takes its time, gnawing slowly at the victims’ minds stealing memories and causing deterioration of brain functions. Alzheimer’s is a disease that causes irreversible dementia and is always fatal.

It was German psychiatrist Dr. Alois Alzheimer who first identified the disease. At first he noted the disease’s symptoms as “amnestic writing disordear,” however when later studies were conducted Dr. Alzheimer found out that the symptoms were more than ordinary memory loss. It was far worse.

Dr. Alzheimer found the presence of neurofibrillary tangles and amyloid plaques in the brain. The good doctor presented his findings which were accepted by the medical community. And soon enough, by 1910 the name of the disease was accepted and became known as Alzheimer’s disease.

The most common early symptoms of the disease are confusion, being inattentive and have problems with orientation, personality changes, experiencing short-term memory loss, language difficulties and mood swings. Probably the most obvious and striking early symptom of Alzheimer’s is loss of short term memory.

At fist the victim will exhibits minor forgetfulness, but as the disease slowly progress he/she will start to forget a lot of things. However, older memories are oftentimes left untouched. Because of this, patients with Alzheimer’s will start to be less energetic and spontaneous. As the disease progress, they will have trouble learning new things and reacting on outside stimuli which gets them all confused and causes them to exercise poor judgment. This is considered Stage 1 of the disease.

At Stage 2 the patient will now need assistance in performing complicated tasks. Speech and understanding is evidently slower. At this stage, Alzheimer’s victims are already aware that they have the disease which causes a whole lot of problems like depression and restlessness.

At this point, only the distant past can be recalled and recent events are immediately forgotten. Patients will have difficulty telling time, date and where they are.

The final stage is of course the hardest, both for the patient and their family. At Stage 3 the patient will start to lose control of a lot of bodily functions like simple chewing and swallowing. He/she will start getting the needed nutrients through a tube. At Stage 3, the patient will no longer remember basically anyone.
They will lose bowel and bladder control and they will become vulnerable to third party infections and diseases like pneumonia.
Once the patient become bedridden, things will only get worse. Respiratory problems will become more terrible.

It is apparent that the patient will need constant care. At this point, the most one can do is to make sure that the patient stays as comfortable as possible. At the terminal stage, death is inevitable.