Category: General Health

Gilbert’s Disease And Its Signs

Many people ask about Gilberts disease and how it affects a person, a lot of people are concerned about having it because there is a little knowledge that can be found about it and there only been a handful of people that are aware that they have it.

How can Gilberts disease go on unnoticed?

One of the main characteristics of Gilberts disease is that it is asymptomatic or it carries no symptoms in most patients. This makes detection and diagnosis really difficult for the doctors and for medical experts. Being asymptomatic in nature makes Gilberts disease one of the few conditions that little are known about. Clinical studies and experimentation is always important in the curing and early detection because the baseline for the condition can be set, the proper dosage for the medication and the duration of the treatment can be directed.

Another factor for the stealth of Gilberts disease is that it has no long term or short term damaging effects to people. This means that patients can live healthy and normal lives and even live to a ripe old age with no hindrances from the condition. The only clear indication that a person has Gilberts disease is if they have experienced jaundice. With only minor stomach pains and yellowish skin and eyes, Gilberts disease causes no great concern to some people.

Other symptoms connected to the condition is uncommon

The person suffering jaundice because of Gilberts disease does not usually cause any major problems, Jaundice is the condition where a person suffers from yellowish skin and eyes and a little stomach pain. However, a number of people with Gilberts disease account other symptoms, the majority of these symptoms are: tiredness, mild weakness, mild abdominal pains and mild nausea. It is not apparent whether these symptoms are in fact connected to Gilberts disease. It is likely that they will build up from time to time due to unsupported nervousness concerning the condition. There does not appear to be any association amid these symptoms and the level of bilirubin in the blood. That is, these symptoms may develop irrelevant to whether or not the level of bilirubin is high or normal.

If the height of bilirubin goes higher than a definite level you turn out to be jaundiced. This is because bilirubin is an orangey-yellow color. A few people with Gilberts disease grow to be a little jaundiced now and then. This might appear to be upsetting, but is of little alarm if the cause is Gilberts disease. It is quite common to be jaundiced if you are a patient of Gilberts disease.

More on the process of breaking down the bilirubin

Jaundicea condition brought about by high levels of bilirubin in the blood stream. For people suffering from Gilberts disease it is caused by the inability of the liver to produce an enzyme that breaks down the bilirubin in the blood and to transfer it to the gut in the form of bilecan be caused by a lot of different diseases of the liver and blood. As a result, if you contract jaundice you are expected to call for tests to make clear the reason and to discard the chance of a serious disease. A blood test can more often than not confirms the diagnosis of Gilberts disease as it demonstrates a mildly raised level of bilirubin and confirms the non-existence of a serious disease.

Diagnosing Gilbert’s Disease

There are times when people go through a certain stage in their lives when they need to understand and adjust to certain changes in the way that they live. Some people are burdened with adjusting to getting married, losing a loved one or acquiring a disease or a medical condition. Of all the three, getting diagnosed with a medical condition can be the hardest to adjust to especially if you found out that you have been living with it for all your life. Hereditary diseases like Gilberts disease are one of those that we can acquire and not know about for a long time.

One of the reasons why we can live without knowing the presence of Gilberts disease is that the condition itself has no symptom or noticeable effect. Some people can even live through the rest of their lives without even knowing.

Just because it has no symptom it doesnt mean that it should not be consulted. People sometimes have the wrong notion of not going to a specialist if they suspect that they have Gilberts disease. So why is it important to have your condition diagnosed? Well there are several reasons but lets just look at one and that is for proper identification of the solution for the the problem, once we have the right diagnosis we can move on to taking care of the person who is sick.

Exclusion of other conditions

While this syndrome Gilberts disease is considered to be harmless by itself, it is clinically important to be diagnosed and identified correctly because it may be confused with much more dangerous liver conditions. However, these will show other indicators of liver dysfunction:

– Hemolysis can be excluded by a full blood count, haptoglobin, lactate dehydrogenase levels and the absence of reticulocytosis (elevated reticulocytes in the blood would usually be observed in haemolytic anaemia);

– Hepatitis can be excluded by negative blood samples for antigens specific to the different hepatitis vira;

– Cholestasis can be excluded by the absence of lactate dehydrogenase, low levels of conjugated bilirubin and ultrasound scan of the bile ducts;

– More severe types of glucoronyl transferase disorders like Crigler-Najjar syndrome (types I and II). These are much more severe and cause brain damage in infancy (type I) and teenage years (type II);

Other diseases of the liver can be exluded by the liver-enzymes ALAT, ASAT and albumin being within normal ranges.

Findings specific to Gilberts syndrome

Patients with Gilberts disease show predominantly elevated unconjugated bilirubin. While conjugated is usually within normal ranges and form less than 20 percent of the total. The level of total bilirubin is often increased if the blood sample is taken after fasting for two days, and a fast can therefore be useful diagnostically. If the total bilirubin does in fact increase while fasting, the patient can then be given low doses of phenobarbital when fasting has ended, and following samples should show a decrease in total bilirubin toward normal levels.

Once the findings have been reported, the patient with Gilberts disease should be more careful and should follow what the physician says. It will also be helpful for him or her to conduct a research so he or she can take care of themselves at home or if they cannot go to the doctor regularly. It is also best to watch diet carefully, conduct regular exercise, and take necessary medications or undergo treatments when needed.

Connecting Liver Disease And Gilbert’s Disease

The human liver is one of the most important organs of the body. It is responsible for cleaning our internal organs of the entire gunk and bile that is deposited by a person on a regular basis. But conditions like Gilberts disease and other forms of liver disease makes our livers weak and prone to breaking down.

To understand better how the liver is affected by different kinds of diseases and the impact of these conditions to our body. Liver disease is a general term used in describing any kind of sickness affecting the liver. Many of theses conditions are accompanied by jaundice caused by the heightened levels of bilirubin in the system. The bilirubin is the product of the breakup of the hemoglobin of dead red blood cells; usually, the liver takes away bilirubin from the blood and excretes it through bile.

The following are some of the known conditions that are considered as liver diseases:

– Hepatitis. This is the inflammation of the liver. This caused mainly by different kinds of viruses, there are also times that it is caused by some poisons, even hereditary conditions.

– Cirrhosis. This is the formation of fibrous tissue in the liver, the fibrous tissue takes the place of dead liver cells.

– Haemochromatosis. This is a hereditary disease caused by too much iron in the body causing liver damage.

– Cancer of the liver. This is usually coming from other parts of the body that is also affected by cancer. Usually, when cancer cells metastasis, it reaches the liver and it starts spreading from there.

– Wilsons disease. This condition is hereditary and copper deposits in the body cause it.

– Budd-Chiari syndrome. This is caused by the obstruction of the persons hepatic vein.

– Gilberts syndrome. This is a genetic disorder of bilirubin metabolism, found in about 5 percent of the population.

– Glycogen storage disease type II. Here, the build-up of glycogen causes progressive tissue weakness (myopathy) throughout the body and affects various body tissues, particularly in the heart, skeletal muscles, liver and nervous system.

There are also many pediatric liver diseases, including biliary atresia, alpha-1 antitrypsin deficiency, alagille syndrome, and progressive familial intrahepatic cholestasis, to name but a few.

A number of liver function tests are available to test the proper function of the liver. These test for the presence of enzymes in blood that are normally most abundant in liver tissue, metabolites or products.

Symptoms of a diseased liver

There are a few external signs that we could include to determine a diseased liver, some of those external signs are a coated tongue, bad breath, skin rashes, itchy skin, excessive sweating, offensive body odor, dark circles under the eyes, red swollen and itchy eyes, acne rosacea, brownish spots and blemishes on the skin, flushed facial appearance or excessive facial blood vessels.

There are other symptoms to look out for and they include jaundice, dark urine, pale stool, bone loss, easy bleeding, itching, small, spider-like blood vessels visible in the skin, enlarged spleen, fluid in the abdominal cavity, chills, pain from the biliary tract or pancrea, and an enlarged gallbladder.

The improper digestion and absorption of fats may lead to symptoms that include indigestion, reflux, hemorrhoids, gall stones, intolerance to fatty foods, intolerance to alcohol, nausea and vomiting attacks, abdominal bloating, and constipation. Unfortunately, some liver diseases like Gilberts disease are known to share symptoms with other liver diseases. So its better to consult a professional.

What You need To Know About Gilbert’s Disease

There are quite a number in the American population that had been affected since their time of birth by this condition, Gilberts disease affects about two to five percent of the population in the United States alone. To better understand what it is and how it affects the people ridden with the condition, here are some of the frequently asked questions about Gilberts disease.

1. What is Gilberts disease? Gilberts disease is known to be one of the causes of mild jaundice once in a while. It is typically not dangerous and has no need for treatment. It is due to a condensed amount of a compounds in the liver, which processes a breakdown result of blood cells called bilirubin. Gilberts disease is a condition wherein the liver has a problem in breaking down the bilirubin completely.

2. Where did the name Gilberts disease came from? In 1901, a French gastroenterologist named Augustin Nicolas Gilbert and his co-workers described the differences in the symptoms of Gilberts disease and the other liver diseases. He also provided additional information on how to acquire it and its further transmission.

3. What is bilirubin and what happens to a person with Gilberts disease? Bilirubin is continuously made inside our bodies, it is a form of end product. It is the waste product of hemoglobin. Hemoglobin is a compound that is found in every persons red blood cells and it is responsible for carrying oxygen to the other cells in the body. Many of the red blood cells that we have and the hemoglobin break down each day and as a result bilirubin needs constant disposal. Bilirubin get carried to the bloodstream and into the liver where it is taken in by liver cells. The liver breaks down the bilirubin further into the gut and to bile. An enzyme or a chemical compound that can be found in liver cells called urodine diphosphate glucuronosyltransferase (UGT) aides the liver cells to break down the bilirubin. People with Gilberts syndrome have a reduced level of UGT and so bilirubin can build up in the bloodstream. High levels of bilirubin in the blood causes jaundice.

4. Who gets Gilberts disease? Gilberts syndrome is a very common hereditary condition that means there is no way to prevent or to treat the condition was it has been passed on to the next generation. About 1 in 20 people have this syndrome – but most will not be aware of it. It is more common in men than women. It is often first diagnosed in the late teens or early twenties.

5. What are the symptoms of Gilberts disease? More often than not, none. Unfortunately, the specific symptoms related to Gilberts disease is not as easy to spot and monitor like in other diseases. Gilberts disease can be very dormant in terms of symptoms that it can manifest in a person for several years with them knowing it.

6. How different is it from jaundice? Jaundice is caused by the excessive levels of bilirubin in the body, more specifically the blood. Because people with Gilberts disease have fluctuating levels of UGT or urodine diphosphate glucuronosyltransferase, the build up and the manifestation of Jaundice cant really be used to gauge the severity of a person with Gilberts diseases condition. Aside from the discomfort and stomach pains most of the other signs of having Gilberts disease can be associated with other conditions.